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Skin Rashes


Skin rash is defined as skin that is not normal in appearance and texture. It is characterized by redness, bumps, blotches, cracks, blisters or swelling and may be accompanied by itching and, in severe cases, by fever. A rash may be localized or may spread to the entire body. If medical attention is not given on time, the problem can worsen.

Skin rashes can have many causes. Each one pertains to a particular condition of the skin or a particular type of disease. It requires the help of a dermatologist to decide what the problem is and what treatment is to be given.

Contact dermatitis is a rash caused by touching something that was previously contaminated or does not suit your body chemistry. Eczema is a skin problem related to people with allergies and asthma. Sebhoric dermatitis deals with flaky skin. If it is on the scalp, it is called dandruff.

Skin rashes are myriad in nature. Each condition is relative to certain problems. Simple problems occur due to allergies to certain foods, detergents, perfumes, plants, etc. Others could be related to diseases like measles, chicken pox, shingles, hand and foot diseases etc. If the problem is considered serious, then you may be advised to have a skin biopsy to rule out diseases like cancer.

These days there are vaccinations available that take care of diseases that could cause rashes. In all cases, it is important to maintain a hygienic routine. When you are affected, find out what products and medications make you break out, and keep this list handy to prevent further problems. As much as possible, avoid over-the-counter remedies except to treat very basic skin problems. Get professional advice and take the required medication, as it is necessary to get rid of the problem at its root.

Most skin conditions need cream or lotion applications to alleviate the problem, and in some cases a course of antibiotics could be prescribed. Read up on some basic medicines, get tips from doctors, and keep a first-aid kit handy and you may prevent a simple rash from turning into a bigger problem.



Source by Kent Pinkerton

Lymphocytes after dark



B cell

When you are infected with a microbe, pieces of the pathogen are picked up by sentinel dendritic cells and brought to local lymph nodes. There the sentinels present their gifts to lymphocytes – B (pictured; image credit) and T cells – who then decide if they are foreign, in which case an immune response begins. These lymphocytes circulate throughout the body not continuously, but in a circadian manner – a 24 hour cycle.

In mice, lymphocyte numbers peak in lymph nodes about one hour after lights are turned off. During the day, these cells leave the lymph nodes. However, the same pattern was observed when mice were kept entirely in the dark, showing that the change in lymphocyte numbers is due to an endogenous circadian clock, not a response to a change in lighting.

The homing of lymphocytes into lymph nodes depends on a number of different proteins, including adhesion molecules and attractants. The levels of these proteins also peaked at night. When the receptor for one attractant, CCR7, was genetically ablated, no oscillations of lymphocyte numbers in lymph nodes was observed.

Dendritic cells, the major antigen presenting cells, are also more numerous in lymph nodes during night hours. This observation makes sense given that dendritic cells present antigen to lymphocytes in the lymph node.

Circadian rhythms are under the control of clock genes – the discovery of which was recently recognized by the Nobel Prize in Physiology or Medicine. Deletion of the gene encoding one such clock gene in B or T cells of mice caused loss of the rhythmicity of lymphocytes in lymph nodes. In these mice, the levels of CCR7 mRNAs also lost their rhythmic character. These observations show that circadian clocks regulate lymphocyte migration.

Earth has a 24 hour day and life has adapted this cycle by turning genes on and off only when needed. It seems reasonable that lymphocyte trafficking into lymph nodes would peak during the hours when animals are moving about and potentially encountering pathogens. But not all animals are diurnal – active during the day. Mice are nocturnal, a behavior that probably helps to avoid predators. It makes perfect sense that lymphocyte trafficking in mice peaks at the onset of night.

It seems likely that in humans, a diurnal species, lymphocyte numbers peak in lymph nodes during the day. Consistent with this idea, it has been shown that in humans, vaccination in the morning produces higher antibody titers compared with vaccination in the afternoon. The take away message is clear: do not get your vaccines at night!



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Date Online and Realize What Potential You Have to Get a Dating Online Match


A dating online match is made everyday by people who have signed up for the dating service. Everyone is looking for a match to start and develop a relationship whether long term or short term. Making this matches might seem to be very easy but, it takes a lot of work. Even after a lot of work has been put into it, the matches are not a guarantee. However, taking the risk will prove to be worth it. There are a lot of factors that will facilitate the making of a dating online match. When you sign up with an online dating site, you will give personal information. This personal information will facilitate the process. In fact, it is through this information that a match can be made at all. Some of the most important necessary points about yourself include the following.

First, the age factor plays a major role in making a dating online match. You need to state accurately what your age is. You will also state the age you are looking for in a partner. If you give false information about yourself, you will only jeopardize your chances of finding a real and great match. This is only if you do not have other motives. Predators of all kinds are some the people who will come with false profiles. Their aim is to entice those who are unsuspecting. The other important thing is profession. Occasionally, the other person will have the opportunity to meet you. Information on your physical appearance is also very important. There are people who are attracted to a certain body type. If you fall short of the expectations, you will ruin your chances of a good relationship.

A dating online match will be made possible due to the above factors. Therefore, make sure you create a suitable profile for this purpose. When you sign up for a good dating online match, beware of the kind of service you are going for. Many services are known to be mediocre. You need to go for people who show some professionalism. Professionalism will emanate from the experience they have in the business. Therefore, it is always vital to know which year they came into being. If people love the particular service, then it might be worth going for. When you find a good service, it is time to open your mind for the possibility of greater diversity. This means that you have a chance to make connections from all corners of the world. Dating online has this as one of the greatest advantage.

A good dating online match needs to meet all the expectations that you may have. The best thing about this kind of dating is that you will never run out of options. If you find that you want to interact with a different culture, this is the best way to do this. You might want to interact this way in the hope of making friends or even finding a better half. People who have done this will tell you that people of different cultures come with a uniqueness that is more interesting than what you are used to.



Source by Francis K Githinji

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